Abstract 51

Title: Rapid Containment of Pseudomonas keratitis by Continuous Infusion of Topical Antibiotics through a Morgan Lens

Author: Whitney Smith, Josh Duncan, Dr. Mingwu Wang, M.D.

Presented by Dr. Wang at the Association for Research in Vision and Ophthalmology conference, Seattle, WA, May, 2016

Purpose: Despite following standard treatment, Pseudomonas keratitis can continue to progress and result in loss of vision or eye. Therefore, rapid containment of aggressive and refractory infection is imperative. Our cases are to demonstrate that Morgan Lens can be an effective topical antibiotic delivery vehicle in cases of advanced keratitis.

Methods: Two patients (three eyes) were included in this report. Patient 1 was an 11-year-old healthy female diagnosed with contact lens-related Pseudomonas keratitis in the right eye. Over a 2-week treatment including topical 15mg/ml tobramycin q1h and ciprofloxacin qid, the keratitis worsened and corneal perforation appeared imminent. Patient 2 was an 11-month old female with  Apert syndrome who was admitted for a complicated pneumonia and on a respirator. Bilateral lagophthalmos led to exposure keratitis and subsequent Pseudomonas keratitis.  Aggressive fortified  antibiotics q1h over two days did not contain the destructive infection. In all affected eyes, a Morgan Lens (MorTan, Inc., Missoula, MT) was inserted under both eyelids, connected to an IV tubing  and the tubing taped to the forehead. In the intubated 11-month old patient with bilateral infections, the Morgan Lens was further secured in place by a temporary tarsorraphy.  Ceftazidime  50mg/ml) was the key antibiotic infused at 20ml/hour through the IV tubing and Morgan Lens over the ocular surface.

Results: Three days after infusion through the Morgan Lens, corneal culture became negative in all eyes. The infusion was continued for at least a week to ensure definitively eradication of  the infection before switching to standard topical antibiotic therapy. Topical steroid and amniotic membrane were used as adjuncts when necessary in the acute recovery phase to control inflammation. A combined cataract and corneal transplant surgeries 9 months later in patient 1 led to a spectacle-corrected vision of 20/60. In patient 2, the corneas remain epithelialized with stable scars and await transplant surgeries after the lagophthalmos are corrected.

Conclusions: The application of the Morgan Lens is non-invasive and requires minimal training. It can timely deliver high concentration antibiotics to the entire ocular surface and possibly, to the intraocular tissues as well. IV tubing connectors allows for easy switch between medications or simultaneous administration of multiple medications, and titration of dosing. Additionally, monitoring of therapeutic effects is not hindered. Our cases suggest that Morgan Lens can be very effective in treating severe and aggressive infectious keratitis or sclerokeratitis.

 

Click here for a PDF file of the ARVO 2016 Annual Meeting Abstracts–scroll down to Program Number 4327.